GLO1 Література | Примітки | Див. також | Навігаційне менюPDBeRCSB1BH51FRO1QIN1QIP3VW93W0T3W0UGLO1957424880GLO1lactoylglutathione lyase activityzinc ion bindingзв'язування з іоном металуlyase activityЦитоплазмаextracellular exosomeклітинне ядроГіалоплазмаЦитоплазматична мембранаregulation of transcription from RNA polymerase II promoterosteoclast differentiationnegative regulation of apoptotic processmethylglyoxal metabolic processglutathione metabolic processpyruvate metabolic processcarbohydrate metabolic processAmigoQuickGOБільше даних2739109801ENSG00000124767ENSMUSG00000024026Q04760Q9CPU0NM_006708NM_001113560NM_025374NP_006699NP_001107032NP_079650Хр. 6: 38.68 – 38.7 MbХр. 17: 30.59 – 30.61 MbPubMed10.1016/S0378-1119(99)00420-5PubMed10.1101/gr.2596504PubMed10.1042/BJ20070379PubMed10.1007/s11010-009-0031-7PubMed10.1093/emboj/16.12.3386PubMed10.1074/jbc.273.34.21623Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:4323UniProt, Q04760виправивши або дописавши їїпідказкою

Гени на хромосомі 6Некатегоризовані білки


англ.амінокислотмолекулярна масаліазфосфопротеїнівальтернативний сплайсингцинку




































GLO1




Наявні структури
PDBПошук ортологів: PDBe RCSB

Ідентифікатори

Символи

GLO1, GLOD1, GLYI, HEL-S-74, glyoxalase I
Зовнішні ІД
MGI: 95742 HomoloGene: 4880 GeneCards: GLO1








Шаблон експресії
PBB GE GLO1 200681 at fs.png

Більше даних
Ортологи
ВидиЛюдинаМиша
Entrez

2739


109801
Ensembl

ENSG00000124767


ENSMUSG00000024026
UniProt

Q04760


Q9CPU0
RefSeq (мРНК)

NM_006708


NM_001113560
NM_025374
RefSeq (білок)

NP_006699

NP_001107032
NP_079650
Локус (UCSC)
Хр. 6: 38.68 – 38.7 Mb

Хр. 17: 30.59 – 30.61 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

GLO1 (англ. Glyoxalase I) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 184 амінокислот, а молекулярна маса — 20 778[4].



Послідовність амінокислот













































1020304050

MAEPQPPSGG

LTDEAALSCC

SDADPSTKDF

LLQQTMLRVK

DPKKSLDFYT

RVLGMTLIQK

CDFPIMKFSL

YFLAYEDKND

IPKEKDEKIA

WALSRKATLE

LTHNWGTEDD

ETQSYHNGNS

DPRGFGHIGI

AVPDVYSACK

RFEELGVKFV

KKPDDGKMKG

LAFIQDPDGY

WIEILNPNKM

ATLM


Кодований геном білок за функціями належить до ліаз, фосфопротеїнів.
Задіяний у таких біологічних процесах, як ацетилювання, альтернативний сплайсинг.
Білок має сайт для зв'язування з іонами металів, іоном цинку.



Література |


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  • Ranganathan S., Ciaccio P.J., Walsh E.S., Tew K.D. (1999). Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.. Gene 240: 149 — 155.  PubMed DOI:10.1016/S0378-1119(99)00420-5


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • de Hemptinne V., Rondas D., Vandekerckhove J., Vancompernolle K. (2007). Tumour necrosis factor induces phosphorylation primarily of the nitric-oxide-responsive form of glyoxalase I.. Biochem. J. 407: 121 — 128.  PubMed DOI:10.1042/BJ20070379


  • de Hemptinne V., Rondas D., Toepoel M., Vancompernolle K. (2009). Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-kappaB.. Mol. Cell. Biochem. 325: 169 — 178.  PubMed DOI:10.1007/s11010-009-0031-7


  • Cameron A.D., Olin B., Ridderstroem M., Mannervik B., Jones T.A. (1997). Crystal structure of human glyoxalase I -- evidence for gene duplication and 3D domain swapping.. EMBO J. 16: 3386 — 3395.  PubMed DOI:10.1093/emboj/16.12.3386


  • Ridderstroem M., Cameron A.D., Jones T.A., Mannervik B. (1998). Involvement of an active-site Zn2+ ligand in the catalytic mechanism of human glyoxalase I.. J. Biol. Chem. 273: 21623 — 21628.  PubMed DOI:10.1074/jbc.273.34.21623



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:4323 (англ.). Процитовано 6 вересня 2017. 


  4. ↑ UniProt, Q04760 (англ.). Процитовано 6 вересня 2017. 



Див. також |


  • Хромосома 6



Молекула міоглобіну
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