UBE2J2 Література | Примітки | Див. також | Навігаційне менюPDBeRCSB2F4WUBE2J2215360810975UBE2J2transferase activitynucleotide bindingATP bindingubiquitin conjugating enzyme activityubiquitin protein ligase bindingubiquitin protein ligase activityintegral component of membraneЕндоплазматичний ретикулуммембранаubiquitin ligase complexendoplasmic reticulum membraneresponse to unfolded proteinprotein polyubiquitinationubiquitin-dependent ERAD pathwaypositive regulation of protein targeting to mitochondrionУбіквітин-залежний протеолізAmigoQuickGO118424140499ENSG00000160087ENSMUSG00000023286Q8N2K1Q6P073NM_058167NM_194315NM_194316NM_194457NM_194458NM_001039157NM_001039158NM_001039159NM_001284312NM_001284314NM_021402NP_477515NP_919296NP_919439NP_919440NP_001034246NP_001034247NP_001034248NP_001271241NP_001271243NP_067377Хр. 1: 1.25 – 1.27 MbХр. 4: 155.94 – 155.96 MbPubMed10.1074/jbc.M007640200PubMed10.1101/gr.2596504Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:19268UniProt, Q8N2K1виправивши або дописавши їїпідказкою

Гени на хромосомі 1Убіквітинлігази


англ.амінокислотмолекулярна масатрансферазвідповідь на порушення конформації білкуальтернативний сплайсингАТФнуклеотидамиендоплазматичному ретикулумі


































UBE2J2




Наявні структури
PDBПошук ортологів: PDBe RCSB

Ідентифікатори

Символи

UBE2J2, NCUBE-2, NCUBE2, PRO2121, ubiquitin conjugating enzyme E2 J2
Зовнішні ІД
MGI: 2153608 HomoloGene: 10975 GeneCards: UBE2J2








Ортологи
ВидиЛюдинаМиша
Entrez

118424


140499
Ensembl

ENSG00000160087


ENSMUSG00000023286
UniProt

Q8N2K1


Q6P073
RefSeq (мРНК)

NM_058167
NM_194315
NM_194316
NM_194457
NM_194458

RefSeq (білок)

NP_477515
NP_919296
NP_919439
NP_919440
Локус (UCSC)
Хр. 1: 1.25 – 1.27 Mb

Хр. 4: 155.94 – 155.96 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

UBE2J2 (англ. Ubiquitin conjugating enzyme E2 J2) – білок, який кодується однойменним геном, розташованим у людей на 1-ї хромосомі.[3] Довжина поліпептидного ланцюга білка становить 259 амінокислот, а молекулярна маса — 28 898[4].



Послідовність амінокислот
























































1020304050

MSSTSSKRAP

TTATQRLKQD

YLRIKKDPVP

YICAEPLPSN

ILEWHYVVRG

PEMTPYEGGY

YHGKLIFPRE

FPFKPPSIYM

ITPNGRFKCN

TRLCLSITDF

HPDTWNPAWS

VSTILTGLLS

FMVEKGPTLG

SIETSDFTKR

QLAVQSLAFN

LKDKVFCELF

PEVVEEIKQK

QKAQDELSSR

PQTLPLPDVV

PDGETHLVQN

GIQLLNGHAP

GAVPNLAGLQ

QANRHHGLLG

GALANLFVIV

GFAAFAYTVK

YVLRSIAQE


Кодований геном білок за функцією належить до трансфераз.
Задіяний у таких біологічних процесах, як відповідь на порушення конформації білку, убіквітинування білків, альтернативний сплайсинг.
Білок має сайт для зв'язування з АТФ, нуклеотидами.
Локалізований у мембрані, ендоплазматичному ретикулумі.



Література |


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  • Tiwari S., Weissman A.M. (2001). Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s).. J. Biol. Chem. 276: 16193 — 16200.  PubMed DOI:10.1074/jbc.M007640200


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:19268 (англ.). Процитовано 18 вересня 2017. 


  4. ↑ UniProt, Q8N2K1 (англ.). Процитовано 18 вересня 2017. 



Див. також |


  • Хромосома 1



Молекула міоглобіну
Це незавершена стаття про білки.
Ви можете допомогти проекту, виправивши або дописавши її.


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