NAB1 Література | Примітки | Див. також | Навігаційне менюPDBeRCSB2YUFNAB11075644352NAB1transcription factor bindingклітинне ядроSchwann cell differentiationmyelinationendochondral ossificationregulation of epidermis developmenttranscription, DNA-templatednegative regulation of transcription, DNA-templatedregulation of transcription, DNA-templatedAmigoQuickGOБільше даних466417936ENSG00000138386ENSMUSG00000002881Q13506Q61122NM_005966NM_001321312NM_001321313NM_001321314NM_001321315NM_008667NP_001308241NP_001308242NP_001308243NP_001308244NP_005957NP_032693Хр. 2: 190.65 – 190.69 MbХр. 1: 52.46 – 52.5 MbPubMed10.1101/gr.2596504PubMed10.1038/embor.2011.152PubMed10.1016/j.celrep.2015.02.033Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:7626UniProt, Q13506виправивши або дописавши їїпідказкою

Гени на хромосомі 2Некатегоризовані білки


англ.амінокислотмолекулярна масарепресорівфосфопротеїнівтранскрипціятранскрипціїальтернативний сплайсингядрі




































NAB1




Наявні структури
PDBПошук ортологів: PDBe RCSB

Ідентифікатори

Символи

NAB1, NGFI-A binding protein 1
Зовнішні ІД
MGI: 107564 HomoloGene: 4352 GeneCards: NAB1








Шаблон експресії

PBB GE NAB1 209272 at fs.png

PBB GE NAB1 211139 s at fs.png

PBB GE NAB1 208047 s at fs.png

Більше даних
Ортологи
ВидиЛюдинаМиша
Entrez

4664


17936
Ensembl

ENSG00000138386


ENSMUSG00000002881
UniProt

Q13506


Q61122
RefSeq (мРНК)

NM_005966
NM_001321312
NM_001321313
NM_001321314
NM_001321315


NM_008667
RefSeq (білок)

NP_001308241
NP_001308242
NP_001308243
NP_001308244
NP_005957

NP_032693
Локус (UCSC)
Хр. 2: 190.65 – 190.69 Mb

Хр. 1: 52.46 – 52.5 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

NAB1 (англ. NGFI-A binding protein 1) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 2-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 487 амінокислот, а молекулярна маса — 54 401[4].



Послідовність амінокислот



































































































1020304050

MAAALPRTLG

ELQLYRILQK

ANLLSYFDAF

IQQGGDDVQQ

LCEAGEEEFL

EIMALVGMAS

KPLHVRRLQK

ALRDWVTNPG

LFNQPLTSLP

VSSIPIYKLP

EGSPTWLGIS

CSSYERSSNA

REPHLKIPKC

AATTCVQSLG

QGKSDVVGSL

ALQSVGESRL

WQGHHATESE

HSLSPADLGS

PASPKESSEA

LDAAAALSVA

ECVERMAPTL

PKSDLNEVKE

LLKTNKKLAK

MIGHIFEMND

DDPHKEEEIR

KYSAIYGRFD

SKRKDGKHLT

LHELTVNEAA

AQLCVKDNAL

LTRRDELFAL

ARQISREVTY

KYTYRTTKSK

CGERDELSPK

RIKVEDGFPD

FQDSVQTLFQ

QARAKSEELA

ALSSQQPEKV

MAKQMEFLCN

QAGYERLQHA

ERRLSAGLYR

QSSEEHSPNG

LTSDNSDGQG

ERPLNLRMPN

LQNRQPHHFV

VDGELSRLYP

SEAKSHSSES

LGILKDYPHS

AFTLEKKVIK

TEPEDSR


Кодований геном білок за функціями належить до репресорів, фосфопротеїнів.
Задіяний у таких біологічних процесах як транскрипція, регуляція транскрипції, альтернативний сплайсинг.
Локалізований у ядрі.



Література |


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  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Garcia-Gutierrez P., Juarez-Vicente F., Gallardo-Chamizo F., Charnay P., Garcia-Dominguez M. (2011). The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.. EMBO Rep. 12: 1018 — 1023.  PubMed DOI:10.1038/embor.2011.152


  • Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C. (2015). SUMO-2 orchestrates chromatin modifiers in response to DNA damage.. Cell Rep. 10: 1778 — 1791.  PubMed DOI:10.1016/j.celrep.2015.02.033



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:7626 (англ.). Процитовано 28 серпня 2017. 


  4. ↑ UniProt, Q13506 (англ.). Процитовано 28 серпня 2017. 



Див. також |


  • Хромосома 2



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