ZCCHC6 Література | Примітки | Див. також | Навігаційне менюTUT7238717951941TUT7transferase activitynucleotidyltransferase activityzinc ion bindingзв'язування з іоном металуnucleic acid bindingRNA bindingRNA uridylyltransferase activityprotein bindingmiRNA bindinguridylyltransferase activityЦитоплазмаnucleoplasmГіалоплазмаhistone mRNA catabolic processRNA 3'-end processingnuclear-transcribed mRNA poly(A) tail shorteningoocyte maturationnegative regulation of transposition, RNA-mediatedmiRNA metabolic processpre-miRNA processingRNA 3' uridylationpolyuridylation-dependent mRNA catabolic processAmigoQuickGOБільше даних79670214290ENSG00000083223ENSMUSG00000035248Q5VYS8Q5BLK4NM_001185059NM_001185074NM_024617NM_001330718NM_153538NP_001171988NP_001172003NP_001317647NP_078893NP_705766Хр. 9: 86.29 – 86.35 MbХр. 13: 59.77 – 59.82 MbPubMed10.1101/gr.2596504PubMed10.1101/gad.1622708PubMed10.1128/MCB.02209-06PubMed10.1261/rna.034538.112Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:25817UniProt, Q5VYS8виправивши або дописавши їїпідказкою

Гени на хромосомі 9Некатегоризовані білки


англ.амінокислотмолекулярна масатрансферазфосфопротеїнівальтернативний сплайсингцинкумагніюіоном марганцюцитоплазмі




































ZCCHC6
Ідентифікатори

Символи

TUT7, PAPD6, zinc finger CCHC-type containing 6, TENT3B, ZCCHC6, terminal uridylyl transferase 7
Зовнішні ІД
MGI: 2387179 HomoloGene: 51941 GeneCards: TUT7








Шаблон експресії
PBB GE ZCCHC6 220933 s at fs.png

Більше даних
Ортологи
ВидиЛюдинаМиша
Entrez

79670


214290
Ensembl

ENSG00000083223


ENSMUSG00000035248
UniProt

Q5VYS8


Q5BLK4
RefSeq (мРНК)

NM_001185059
NM_001185074
NM_024617
NM_001330718


NM_153538
RefSeq (білок)

NP_001171988
NP_001172003
NP_001317647
NP_078893

NP_705766
Локус (UCSC)
Хр. 9: 86.29 – 86.35 Mb

Хр. 13: 59.77 – 59.82 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

ZCCHC6 (англ. Zinc finger CCHC-type containing 6) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 1 495 амінокислот, а молекулярна маса — 171 229[4].



Послідовність амінокислот

























































































































































































































































































1020304050

MGDTAKPYFV

KRTKDRGTMD

DDDFRRGHPQ

QDYLIIDDHA

KGHGSKMEKG

LQKKKITPGN

YGNTPRKGPC

AVSSNPYAFK

NPIYSQPAWM

NDSHKDQSKR

WLSDEHTGNS

DNWREFKPGP

RIPVINRQRK

DSFQENEDGY

RWQDTRGCRT

VRRLFHKDLT

SLETTSEMEA

GSPENKKQRS

RPRKPRKTRN

EENEQDGDLE

GPVIDESVLS

TKELLGLQQA

EERLKRDCID

RLKRRPRNYP

TAKYTCRLCD

VLIESIAFAH

KHIKEKRHKK

NIKEKQEEEL

LTTLPPPTPS

QINAVGIAID

KVVQEFGLHN

ENLEQRLEIK

RIMENVFQHK

LPDCSLRLYG

SSCSRLGFKN

SDVNIDIQFP

AIMSQPDVLL

LVQECLKNSD

SFIDVDADFH

ARVPVVVCRE

KQSGLLCKVS

AGNENACLTT

KHLTALGKLE

PKLVPLVIAF

RYWAKLCSID

RPEEGGLPPY

VFALMAIFFL

QQRKEPLLPV

YLGSWIEGFS

LSKLGNFNLQ

DIEKDVVIWE

HTDSAAGDTG

ITKEEAPRET

PIKRGQVSLI

LDVKHQPSVP

VGQLWVELLR

FYALEFNLAD

LVISIRVKEL

VSRELKDWPK

KRIAIEDPYS

VKRNVARTLN

SQPVFEYILH

CLRTTYKYFA

LPHKITKSSL

LKPLNAITCI

SEHSKEVINH

HPDVQTKDDK

LKNSVLAQGP

GATSSAANTC

KVQPLTLKET

AESFGSPPKE

EMGNEHISVH

PENSDCIQAD

VNSDDYKGDK

VYHPETGRKN

EKEKVGRKGK

HLLTVDQKRG

EHVVCGSTRN

NESESTLDLE

GFQNPTAKEC

EGLATLDNKA

DLDGESTEGT

EELEDSLNHF

THSVQGQTSE

MIPSDEEEED

DEEEEEEEEP

RLTINQREDE

DGMANEDELD

NTYTGSGDED

ALSEEDDELG

EAAKYEDVKE

CGKHVERALL

VELNKISLKE

ENVCEEKNSP

VDQSDFFYEF

SKLIFTKGKS

PTVVCSLCKR

EGHLKKDCPE

DFKRIQLEPL

PPLTPKFLNI

LDQVCIQCYK

DFSPTIIEDQ

AREHIRQNLE

SFIRQDFPGT

KLSLFGSSKN

GFGFKQSDLD

VCMTINGLET

AEGLDCVRTI

EELARVLRKH

SGLRNILPIT

TAKVPIVKFF

HLRSGLEVDI

SLYNTLALHN

TRLLSAYSAI

DPRVKYLCYT

MKVFTKMCDI

GDASRGSLSS

YAYTLMVLYF

LQQRNPPVIP

VLQEIYKGEK

KPEIFVDGWN

IYFFDQIDEL

PTYWSECGKN

TESVGQLWLG

LLRFYTEEFD

FKEHVISIRR

KSLLTTFKKQ

WTSKYIVIED

PFDLNHNLGA

GLSRKMTNFI

MKAFINGRRV

FGIPVKGFPK

DYPSKMEYFF

DPDVLTEGEL

APNDRCCRIC

GKIGHFMKDC

PMRRKVRRRR

DQEDALNQRY

PENKEKRSKE

DKEIHNKYTE

REVSTKEDKP

IQCTPQKAKP

MRAAADLGRE

KILRPPVEKW

KRQDDKDLRE

KRCFICGREG

HIKKECPQFK

GSSGSLSSKY

MTQGKASAKR

TQQES


Кодований геном білок за функціями належить до трансфераз, фосфопротеїнів.
Задіяний у такому біологічному процесі, як альтернативний сплайсинг.
Білок має сайт для зв'язування з іонами металів, іоном цинку, іоном магнію, іоном марганцю.
Локалізований у цитоплазмі.



Література |


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Mullen T.E., Marzluff W.F. (2008). Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.. Genes Dev. 22: 50 — 65.  PubMed DOI:10.1101/gad.1622708


  • Rissland O.S., Mikulasova A., Norbury C.J. (2007). Efficient RNA polyuridylation by noncanonical poly(A) polymerases.. Mol. Cell. Biol. 27: 3612 — 3624.  PubMed DOI:10.1128/MCB.02209-06


  • Thornton J.E., Chang H.M., Piskounova E., Gregory R.I. (2012). Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).. RNA 18: 1875 — 1885.  PubMed DOI:10.1261/rna.034538.112



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:25817 (англ.). Процитовано 8 вересня 2017. 


  4. ↑ UniProt, Q5VYS8 (англ.). Процитовано 8 вересня 2017. 



Див. також |


  • Хромосома 9



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