CDK15 Література | Примітки | Див. також | Навігаційне менюCDK15358394464641CDK15transferase activitynucleotide bindingprotein kinase activityprotein serine/threonine kinase activityprotein bindingATP bindingзв'язування з іоном металуkinase activitycyclin-dependent protein serine/threonine kinase activitycyclin bindingклітинне ядроГіалоплазмаЦитоплазмаprotein phosphorylationфосфорилюванняregulation of cell cycleAmigoQuickGO65061271697ENSG00000138395ENSMUSG00000026023Q96Q40Q3V3A1NM_001261435NM_001261436NM_139158NM_001366386NM_001033373NM_001356389NP_001248364NP_001248365NP_631897NP_001353315NP_001028545NP_001343318Хр. 2: 201.79 – 201.9 MbХр. 1: 59.26 – 59.35 MbPubMed10.1101/gr.2596504PubMed10.1126/science.1075762PubMed10.1016/j.bbrc.2014.05.070Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:14434UniProt, Q96Q40виправивши або дописавши їїпідказкою

Гени на хромосомі 2Протеїнкінази


англ.амінокислотмолекулярна масаАланінЦистеїнАспарагінова кислотаГлутамінова кислотаФенілаланінГліцинГістидинІзолейцинЛізинЛейцинМетіонінАспарагінПролінГлутамінАргінінСеринТреонінВалінТриптофантрансферазкіназпротеїнкіназальтернативний сплайсингАТФнуклеотидамимагнію


































CDK15
Ідентифікатори

Символи

CDK15, ALS2CR7, PFTAIRE2, PFTK2, cyclin-dependent kinase 15, cyclin dependent kinase 15
Зовнішні ІД
MGI: 3583944 HomoloGene: 64641 GeneCards: CDK15








Ортологи
ВидиЛюдинаМиша
Entrez

65061


271697
Ensembl

ENSG00000138395


ENSMUSG00000026023
UniProt

Q96Q40


Q3V3A1
RefSeq (мРНК)

NM_001261435
NM_001261436
NM_139158
NM_001366386


NM_001033373
NM_001356389
RefSeq (білок)

NP_001248364
NP_001248365
NP_631897
NP_001353315

NP_001028545
NP_001343318
Локус (UCSC)
Хр. 2: 201.79 – 201.9 Mb

Хр. 1: 59.26 – 59.35 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

CDK15 (англ. Cyclin dependent kinase 15) – білок, який кодується однойменним геном, розташованим у людей на 2-ї хромосомі.[3] Довжина поліпептидного ланцюга білка становить 435 амінокислот, а молекулярна маса — 49 023[4].



Послідовність амінокислот


























































































1020304050
MGQELCAKTVQPGCSCYHCSEGGEAHSCRRSQPETTEAAFKLTDLKEASC
SMTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAA
SSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREA
SLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHN
VRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKS
IPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLF
PGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVV
WNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE
ESLFTVSGVRLKPEMCDLLASYQKGHHPAQFSKCW

A: Аланін

C: Цистеїн

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан


Y: Тирозин



Кодований геном білок за функціями належить до трансфераз, кіназ, серин/треонінових протеїнкіназ.
Задіяний у такому біологічному процесі, як альтернативний сплайсинг.
Білок має сайт для зв'язування з АТФ, нуклеотидами, іонами металів, іоном магнію.



Література |


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. (2002). The protein kinase complement of the human genome.. Science 298: 1912 — 1934.  PubMed DOI:10.1126/science.1075762


  • Park M.H., Kim S.Y., Kim Y.J., Chung Y.H. (2014). ALS2CR7 (CDK15) attenuates TRAIL induced apoptosis by inducing phosphorylation of survivin Thr34.. Biochem. Biophys. Res. Commun. 450: 129 — 134.  PubMed DOI:10.1016/j.bbrc.2014.05.070



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:14434 (англ.). Процитовано 18 вересня 2017. 


  4. ↑ UniProt, Q96Q40 (англ.). Процитовано 18 вересня 2017. 



Див. також |


  • Хромосома 2



Молекула міоглобіну
Це незавершена стаття про білки.
Ви можете допомогти проекту, виправивши або дописавши її.


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