ALYREF Література | Примітки | Див. також | Навігаційне менюPDBeRCSB3ULHALYREF134554ALYREFprotein bindingnucleic acid bindingRNA bindingЦитоплазмаГіалоплазмаnuclear speckcatalytic step 2 spliceosomeмембранаtranscription export complexexon-exon junction complexspliceosomal complexextracellular exosomenuclear chromosome, telomeric regionклітинне ядроnucleoplasmregulation of DNA recombinationmRNA splicing, via spliceosometermination of RNA polymerase II transcriptionmRNA transportmRNA processingviral mRNA export from host cell nucleusmRNA export from nucleuspositive regulation of DNA-templated transcription, elongationosteoblast differentiationreplication fork processingviral processmRNA 3'-end processingСплайсингRNA export from nucleusтранспортAmigoQuickGO10189690585ENSG00000183684ENSRNOG00000036687Q86V81D3ZXH7NM_005782NM_001109602NP_005773NP_001103072Хр. 17: 81.89 – 81.89 MbPubMed10.1101/gr.2596504PubMed10.1016/S0198-8859(98)00085-8PubMed10.1101/gr.473902PubMed10.1016/S1097-2765(00)80369-XPubMed10.1093/emboj/19.24.6860PubMed10.1093/emboj/20.22.6424Human PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:19071UniProt, Q86V81виправивши або дописавши їїпідказкою

Гени на хромосомі 17Некатегоризовані білки


англ.амінокислотмолекулярна масаАланінАспарагінова кислотаГлутамінова кислотаФенілаланінГліцинГістидинІзолейцинЛізинЛейцинМетіонінАспарагінПролінГлутамінАргінінСеринТреонінВалінТриптофаншапероніввіруспроцесінг мРНКсплайсінгРНКцитоплазміядрі


































ALYREF
Protein THOC4 PDB 1no8.png




Наявні структури
PDBПошук ортологів: PDBe RCSB

Ідентифікатори

Символи

ALYREF, ALY, ALY/REF, BEF, REF, THOC4, Aly/REF export factor
Зовнішні ІД
HomoloGene: 134554 GeneCards: ALYREF








Ортологи
ВидиЛюдинаМиша
Entrez

10189


690585
Ensembl

ENSG00000183684


ENSRNOG00000036687
UniProt

Q86V81


D3ZXH7
RefSeq (мРНК)

NM_005782


NM_001109602
RefSeq (білок)

NP_005773

NP_001103072
Локус (UCSC)
Хр. 17: 81.89 – 81.89 Mb

н/д

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

ALYREF (англ. Aly/REF export factor) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 17-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 257 амінокислот, а молекулярна маса — 26 888[4].



Послідовність амінокислот
























































1020304050
MADKMDMSLDDIIKLNRSQRGGRGGGRGRGRAGSQGGRGGGAQAAARVNR
GGGPIRNRPAIARGAAGGGGRNRPAPYSRPKQLPDKWQHDLFDSGFGGGA
GVETGGKLLVSNLDFGVSDADIQELFAEFGTLKKAAVHYDRSGRSLGTAD
VHFERKADALKAMKQYNGVPLDGRPMNIQLVTSQIDAQRRPAQSVNRGGM
TRNRGAGGFGGGGGTRRGTRGGARGRGRGAGRNSKQQLSAEELDAQLDAY
NARMDTS

A: Аланін

D: Аспарагінова кислота

E: Глутамінова кислота

F: Фенілаланін

G: Гліцин

H: Гістидин

I: Ізолейцин

K: Лізин

L: Лейцин

M: Метіонін

N: Аспарагін

P: Пролін

Q: Глутамін

R: Аргінін

S: Серин

T: Треонін

V: Валін

W: Триптофан


Y: Тирозин



Кодований геном білок за функцією належить до шаперонів.
Задіяний у таких біологічних процесах як взаємодія хазяїн-вірус, процесінг мРНК, сплайсінг мРНК, транспорт, транспорт мРНК.
Білок має сайт для зв'язування з РНК.
Локалізований у цитоплазмі, ядрі.



Література |


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Wichmann I., Garcia-Lozano J.R., Respaldiza N., Gonzalez-Escribano M.F., Nunez-Roldan A. (1999). Autoantibodies to transcriptional regulation proteins DEK and ALY in a patient with systemic lupus erythematosus.. Hum. Immunol. 60: 57 — 62.  PubMed DOI:10.1016/S0198-8859(98)00085-8


  • Rappsilber J., Ryder U., Lamond A.I., Mann M. (2002). Large-scale proteomic analysis of the human spliceosome.. Genome Res. 12: 1231 — 1245.  PubMed DOI:10.1101/gr.473902


  • Virbasius C.-M., Wagner S., Green M.R. (1999). A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins.. Mol. Cell 4: 219 — 228.  PubMed DOI:10.1016/S1097-2765(00)80369-X


  • Le Hir H., Izaurralde E., Maquat L.E., Moore M.J. (2000). The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.. EMBO J. 19: 6860 — 6869.  PubMed DOI:10.1093/emboj/19.24.6860


  • Kataoka N., Diem M.D., Kim V.N., Yong J., Dreyfuss G. (2001). Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex.. EMBO J. 20: 6424 — 6433.  PubMed DOI:10.1093/emboj/20.22.6424



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:19071 (англ.). Процитовано 27 лютого 2017. 


  4. ↑ UniProt, Q86V81 (англ.). Процитовано 27 лютого 2017. 



Див. також |


  • Хромосома 17



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