PC (ген) Література | Примітки | Див. також | Навігаційне менюPDBeRCSB3BG33BG9PC975205422PCnucleotide bindingbiotin bindingзв'язування з іоном металуpyruvate carboxylase activityligase activityprotein bindingcatalytic activityATP bindingidentical protein bindingЦитоплазмаГіалоплазмамітохондріальний матриксмітохондріяГлюконеогенезpositive regulation by host of viral release from host cellbiotin metabolic processLipid metabolismnegative regulation of gene expressionpositive regulation by host of viral processpyruvate metabolic processviral RNA genome packagingОбмін речовинAmigoQuickGO509118563ENSG00000173599ENSMUSG00000024892P11498Q05920NM_000920NM_001040716NM_022172NM_001162946NM_008797NP_000911NP_001035806NP_071504Хр. 11: 66.85 – 66.96 MbХр. 19: 4.51 – 4.62 MbPubMed10.1006/bbrc.1994.2029PubMed10.1101/gr.2596504PubMed10.1016/0003-9861(87)90146-9PubMed10.1038/nsmb.1393PubMedЗахворювання, генетично пов'язані з PC переглянути/редагувати посилання на ВікіДанихHuman PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:8636UniProt, P11498виправивши або дописавши їїпідказкою

Гени на хромосомі 11Некатегоризовані білки


англ.амінокислотмолекулярна масалігазфосфопротеїнівліпідівглюконеогенезальтернативний сплайсингАТФнуклеотидамимолекулою піровиноградної кислотиіоном марганцюмітохондрії




































PC




Наявні структури
PDBПошук ортологів: PDBe RCSB

Ідентифікатори

Символи

PC, pyruvate carboxylase, PCB
Зовнішні ІД
MGI: 97520 HomoloGene: 5422 GeneCards: PC

Пов'язані генетичні захворювання

human immunodeficiency virus infectious disease[1]








Ортологи
ВидиЛюдинаМиша
Entrez

5091


18563
Ensembl

ENSG00000173599


ENSMUSG00000024892
UniProt

P11498


Q05920
RefSeq (мРНК)

NM_000920
NM_001040716
NM_022172


NM_001162946
NM_008797
RefSeq (білок)

NP_000911
NP_001035806
NP_071504

н/д
Локус (UCSC)
Хр. 11: 66.85 – 66.96 Mb

Хр. 19: 4.51 – 4.62 Mb

PubMed search
[2]
[3]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

PC (англ. Pyruvate carboxylase) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 11-ї хромосоми.[4] Довжина поліпептидного ланцюга білка становить 1 178 амінокислот, а молекулярна маса — 129 634[5].



Послідовність амінокислот































































































































































































































1020304050

MLKFRTVHGG

LRLLGIRRTS

TAPAASPNVR

RLEYKPIKKV

MVANRGEIAI

RVFRACTELG

IRTVAIYSEQ

DTGQMHRQKA

DEAYLIGRGL

APVQAYLHIP

DIIKVAKENN

VDAVHPGYGF

LSERADFAQA

CQDAGVRFIG

PSPEVVRKMG

DKVEARAIAI

AAGVPVVPGT

DAPITSLHEA

HEFSNTYGFP

IIFKAAYGGG

GRGMRVVHSY

EELEENYTRA

YSEALAAFGN

GALFVEKFIE

KPRHIEVQIL

GDQYGNILHL

YERDCSIQRR

HQKVVEIAPA

AHLDPQLRTR

LTSDSVKLAK

QVGYENAGTV

EFLVDRHGKH

YFIEVNSRLQ

VEHTVTEEIT

DVDLVHAQIH

VAEGRSLPDL

GLRQENIRIN

GCAIQCRVTT

EDPARSFQPD

TGRIEVFRSG

EGMGIRLDNA

SAFQGAVISP

HYDSLLVKVI

AHGKDHPTAA

TKMSRALAEF

RVRGVKTNIA

FLQNVLNNQQ

FLAGTVDTQF

IDENPELFQL

RPAQNRAQKL

LHYLGHVMVN

GPTTPIPVKA

SPSPTDPVVP

AVPIGPPPAG

FRDILLREGP

EGFARAVRNH

PGLLLMDTTF

RDAHQSLLAT

RVRTHDLKKI

APYVAHNFSK

LFSMENWGGA

TFDVAMRFLY

ECPWRRLQEL

RELIPNIPFQ

MLLRGANAVG

YTNYPDNVVF

KFCEVAKENG

MDVFRVFDSL

NYLPNMLLGM

EAAGSAGGVV

EAAISYTGDV

ADPSRTKYSL

QYYMGLAEEL

VRAGTHILCI

KDMAGLLKPT

ACTMLVSSLR

DRFPDLPLHI

HTHDTSGAGV

AAMLACAQAG

ADVVDVAADS

MSGMTSQPSM

GALVACTRGT

PLDTEVPMER

VFDYSEYWEG

ARGLYAAFDC

TATMKSGNSD

VYENEIPGGQ

YTNLHFQAHS

MGLGSKFKEV

KKAYVEANQM

LGDLIKVTPS

SKIVGDLAQF

MVQNGLSRAE

AEAQAEELSF

PRSVVEFLQG

YIGVPHGGFP

EPFRSKVLKD

LPRVEGRPGA

SLPPLDLQAL

EKELVDRHGE

EVTPEDVLSA

AMYPDVFAHF

KDFTATFGPL

DSLNTRLFLQ

GPKIAEEFEV

ELERGKTLHI

KALAVSDLNR

AGQRQVFFEL

NGQLRSILVK

DTQAMKEMHF

HPKALKDVKG

QIGAPMPGKV

IDIKVVAGAK

VAKGQPLCVL

SAMKMETVVT

SPMEGTVRKV

HVTKDMTLEG

DDLILEIE


Кодований геном білок за функціями належить до лігаз, фосфопротеїнів.
Задіяний у таких біологічних процесах, як метаболізм ліпідів, глюконеогенез, біосинтез ліпідів, ацетилювання, альтернативний сплайсинг.
Білок має сайт для зв'язування з АТФ, нуклеотидами, іонами металів, молекулою піровиноградної кислоти, іоном марганцю.
Локалізований у мітохондрії.



Література |


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  • Mackay N., Rigat B., Douglas C., Chen H.S., Robinson B.H. (1994). cDNA cloning of human kidney pyruvate carboxylase.. Biochem. Biophys. Res. Commun. 202: 1009 — 1014.  PubMed DOI:10.1006/bbrc.1994.2029


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Lamhonwah A.-M., Quan F., Gravel R.A. (1987). Sequence homology around the biotin-binding site of human propionyl-CoA carboxylase and pyruvate carboxylase.. Arch. Biochem. Biophys. 254: 631 — 636.  PubMed DOI:10.1016/0003-9861(87)90146-9


  • Xiang S., Tong L. (2008). Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.. Nat. Struct. Mol. Biol. 15: 295 — 302.  PubMed DOI:10.1038/nsmb.1393


  • Freytag S.O., Collier K.J. (1984). Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes.. J. Biol. Chem. 259: 12831 — 12837.  PubMed



Примітки |




  1. ↑ Захворювання, генетично пов'язані з PC переглянути/редагувати посилання на ВікіДаних. 


  2. ↑ Human PubMed Reference:. 


  3. ↑ Mouse PubMed Reference:. 


  4. ↑ HUGO Gene Nomenclature Commitee, HGNC:8636 (англ.). Процитовано 8 вересня 2017. 


  5. ↑ UniProt, P11498 (англ.). Процитовано 8 вересня 2017. 



Див. також |


  • Хромосома 11



Молекула міоглобіну
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