MYF6 Література | Примітки | Див. також | Навігаційне менюMYF6972531850MYF6DNA bindingprotein dimerization activitytranscription factor activity, sequence-specific DNA bindingtranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingRNA polymerase II core promoter proximal region sequence-specific DNA bindingE-box bindingprotein heterodimerization activitytranscription factor activity, RNA polymerase II distal enhancer sequence-specific bindingRNA polymerase II transcription factor activity, sequence-specific DNA bindingnucleoplasmRNA polymerase II transcription factor complexклітинне ядроsomitogenesisДиференціація клітинregulation of transcription, DNA-templatedpositive regulation of muscle cell differentiationregulation of transcription from RNA polymerase II promotermuscle cell fate commitmentmuscle organ developmenttranscription from RNA polymerase II promoterpositive regulation of skeletal muscle fiber developmentmulticellular organism developmentpositive regulation of transcription, DNA-templatedpositive regulation of myoblast fusionskeletal muscle tissue regenerationpositive regulation of myoblast differentiationmuscle tissue morphogenesisskeletal muscle cell differentiationnegative regulation of transcription, DNA-templatedskeletal muscle tissue developmentpositive regulation of transcription from RNA polymerase II promoterAmigoQuickGO461817878ENSG00000111046ENSMUSG00000035923P23409P15375NM_002469NM_008657NP_002460NP_032683Хр. 12: 80.71 – 80.71 MbХр. 10: 107.49 – 107.49 MbPubMed10.1101/gr.2596504PubMedHuman PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:7566UniProt, P23409виправивши або дописавши їїпідказкою

Гени на хромосомі 12Некатегоризовані білки


англ.амінокислотмолекулярна масабілків розвиткудиференціація клітинДНКядрі


































MYF6
Ідентифікатори

Символи

MYF6, CNM3, MRF4, bHLHc4, myf-6, Myf6, myogenic factor 6
Зовнішні ІД
MGI: 97253 HomoloGene: 1850 GeneCards: MYF6








Ортологи
ВидиЛюдинаМиша
Entrez

4618


17878
Ensembl

ENSG00000111046


ENSMUSG00000035923
UniProt

P23409


P15375
RefSeq (мРНК)

NM_002469


NM_008657
RefSeq (білок)

NP_002460

NP_032683
Локус (UCSC)
Хр. 12: 80.71 – 80.71 Mb

Хр. 10: 107.49 – 107.49 Mb

PubMed search
[1]
[2]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

MYF6 (англ. Myogenic factor 6) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 12-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 242 амінокислот, а молекулярна маса — 26 953[4].



Послідовність амінокислот
























































1020304050

MMMDLFETGS

YFFYLDGENV

TLQPLEVAEG

SPLYPGSDGT

LSPCQDQMPP

EAGSDSSGEE

HVLAPPGLQP

PHCPGQCLIW

ACKTCKRKSA

PTDRRKAATL

RERRRLKKIN

EAFEALKRRT

VANPNQRLPK

VEILRSAISY

IERLQDLLHR

LDQQEKMQEL

GVDPFSYRPK

QENLEGADFL

RTCSSQWPSV

SDHSRGLVIT

AKEGGASIDS

SASSSLRCLS

SIVDSISSEE

RKLPCVEEVV

EK


Кодований геном білок за функцією належить до білків розвитку.
Задіяний у таких біологічних процесах, як диференціація клітин, міогенез.
Білок має сайт для зв'язування з ДНК.
Локалізований у ядрі.



Література |


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  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


  • Braun T., Bober E., Winter B., Rosenthal N., Arnold H.H. (1990). Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12.. EMBO J. 9: 821 — 831.  PubMed


  • Kerst B., Perrot A., Osterziel K.-J., Huebner C., Speer A. (1998). MYF6 mutations resulting in A112S and A90D substitutions in patients with skeletal or cardiac muscle pathology.. Hum. Mutat. 12: 220 — 220. 



Примітки |




  1. ↑ Human PubMed Reference:. 


  2. ↑ Mouse PubMed Reference:. 


  3. ↑ HUGO Gene Nomenclature Commitee, HGNC:7566 (англ.). Процитовано 11 вересня 2017. 


  4. ↑ UniProt, P23409 (англ.). Процитовано 11 вересня 2017. 



Див. також |


  • Хромосома 12



Молекула міоглобіну
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Ви можете допомогти проекту, виправивши або дописавши її.


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