DAGLB Література | Примітки | Див. також | Навігаційне менюDAGLB244203234715DAGLBhydrolase activityзв'язування з іоном металуacylglycerol lipase activityintegral component of membranelysosomal membraneЦитоплазматична мембранамембранаклітинне ядроpostsynaptic membraneneuroblast proliferationlipid catabolic processneurogenesisneurotransmitter biosynthetic processarachidonic acid metabolic processLipid metabolismG-protein coupled glutamate receptor signaling pathwaydiacylglycerol catabolic processendocannabinoid signaling pathwayretrograde trans-synaptic signaling by endocannabinoidAmigoQuickGO221955231871ENSG00000164535ENSMUSG00000039206Q8NCG7Q91WC9NM_139179NM_001142936NM_144915NP_001136408NP_631918NP_659164Хр. 7: 6.41 – 6.48 MbХр. 5: 143.46 – 143.51 MbPubMed10.1101/gr.2596504Сполуки, які фізично взаємодіють з Diacylglycerol lipase beta переглянути/редагувати посилання на ВікіДанихHuman PubMed Reference:Mouse PubMed Reference:HUGO Gene Nomenclature Commitee, HGNC:28923UniProt, Q8NCG7виправивши або дописавши їїпідказкою

Гени на хромосомі 7Некатегоризовані білки


англ.амінокислотмолекулярна масагідролазфосфопротеїнівліпідівліпідівальтернативний сплайсингкальціюклітинній мембрані




































DAGLB
Ідентифікатори

Символи

DAGLB, DAGLBETA, KCCR13L, diacylglycerol lipase beta
Зовнішні ІД
MGI: 2442032 HomoloGene: 34715 GeneCards: DAGLB

Реагує на сполуку

orlistat, RHC80267[1]








Ортологи
ВидиЛюдинаМиша
Entrez

221955


231871
Ensembl

ENSG00000164535


ENSMUSG00000039206
UniProt

Q8NCG7


Q91WC9
RefSeq (мРНК)

NM_139179
NM_001142936


NM_144915
RefSeq (білок)

NP_001136408
NP_631918

NP_659164
Локус (UCSC)
Хр. 7: 6.41 – 6.48 Mb

Хр. 5: 143.46 – 143.51 Mb

PubMed search
[2]
[3]
Вікідані


Див./Ред. для людейДив./Ред. для мишей

DAGLB (англ. Diacylglycerol lipase beta) – білок, який кодується однойменним геном, розташованим у людей на 7-ї хромосомі.[4] Довжина поліпептидного ланцюга білка становить 672 амінокислот, а молекулярна маса — 73 732[5].



Послідовність амінокислот





































































































































1020304050

MPGMVLFGRR

WAIASDDLVF

PGFFELVVRV

LWWIGILTLY

LMHRGKLDCA

GGALLSSYLI

VLMILLAVVI

CTVSAIMCVS

MRGTICNPGP

RKSMSKLLYI

RLALFFPEMV

WASLGAAWVA

DGVQCDRTVV

NGIIATVVVS

WIIIAATVVS

IIIVFDPLGG

KMAPYSSAGP

SHLDSHDSSQ

LLNGLKTAAT

SVWETRIKLL

CCCIGKDDHT

RVAFSSTAEL

FSTYFSDTDL

VPSDIAAGLA

LLHQQQDNIR

NNQEPAQVVC

HAPGSSQEAD

LDAELENCHH

YMQFAAAAYG

WPLYIYRNPL

TGLCRIGGDC

CRSRTTDYDL

VGGDQLNCHF

GSILHTTGLQ

YRDFIHVSFH

DKVYELPFLV

ALDHRKESVV

VAVRGTMSLQ

DVLTDLSAES

EVLDVECEVQ

DRLAHKGISQ

AARYVYQRLI

NDGILSQAFS

IAPEYRLVIV

GHSLGGGAAA

LLATMLRAAY

PQVRCYAFSP

PRGLWSKALQ

EYSQSFIVSL

VLGKDVIPRL

SVTNLEDLKR

RILRVVAHCN

KPKYKILLHG

LWYELFGGNP

NNLPTELDGG

DQEVLTQPLL

GEQSLLTRWS

PAYSFSSDSP

LDSSPKYPPL

YPPGRIIHLQ

EEGASGRFGC

CSAAHYSAKW

SHEAEFSKIL

IGPKMLTDHM

PDILMRALDS

VVSDRAACVS

CPAQGVSSVD

VA


Кодований геном білок за функціями належить до гідролаз, фосфопротеїнів.
Задіяний у таких біологічних процесах, як метаболізм ліпідів, деградація ліпідів, альтернативний сплайсинг.
Білок має сайт для зв'язування з іонами металів, іоном кальцію.
Локалізований у клітинній мембрані, мембрані.



Література |


.mw-parser-output .refbeginfont-size:90%;margin-bottom:0.5em.mw-parser-output .refbegin-hanging-indents>ullist-style-type:none;margin-left:0.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>ddmargin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none.mw-parser-output .refbegin-100font-size:100%


  • The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14: 2121 — 2127. 2004.  PubMed DOI:10.1101/gr.2596504


Примітки |




  1. ↑ Сполуки, які фізично взаємодіють з Diacylglycerol lipase beta переглянути/редагувати посилання на ВікіДаних. 


  2. ↑ Human PubMed Reference:. 


  3. ↑ Mouse PubMed Reference:. 


  4. ↑ HUGO Gene Nomenclature Commitee, HGNC:28923 (англ.). Процитовано 19 вересня 2017. 


  5. ↑ UniProt, Q8NCG7 (англ.). Процитовано 19 вересня 2017. 



Див. також |


  • Хромосома 7



Молекула міоглобіну
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